What are the therapeutic indications of Lyrica?
Lyrica has a remarkable application in the management of nerve pain caused by nerve damage or injury because of diabetic neuropathy or to shingles (herpes zoster) infection. It is also safe and effective in the treatment of nerve pain caused by spinal cord damage. It helps a person to obtain instant relief from fibromyalgia. Lyrica is taken along with other drugs for the treatment of epileptic seizures. Pregabalin is a chief component of Lyrica.
How does Lyrica work?
Pregabalin binds to the alpha2-delta subunit of voltage-gated calcium channels present in CNS. It reduces the calcium-dependent liberation of numerous neurotransmitters by modifying the role of calcium channels. The anti-Nociceptive action of Pregabalin is mediated through interactions with downward noradrenergic and serotonergic receptor originating from the brainstem that makes some changes in the pain transmission and enhances the pain threshold in the spinal cord.
What is the dosing schedule of Lyrica?
Commercially, Lyrica capsule is accessible in different dosing strengths of 25mg, 50mg, 75mg, 150mg, and 300mg. Dose for the treatment of nerve pain linked with diabetic peripheral neuropathy: A patient should consume 100mg of Lyrica orally thrice a day, with an ample amount of water. Dose for the treatment of Postherpetic Neuralgia: A patient should consume 75 to 150 mg of Lyrica orally twice a day or 50 to 100 mg of Lyrica thrice a day, with sufficient amount of water. Dose for the treatment of Fibromyalgia: A patient should consume 300 to 450 mg of Lyrica orally per day in divided doses, with a colossal amount of water. Dose for the treatment of nerve pain associated with spinal cord injury: A patient should consume 150mg to 600mg of Lyrica orally per day, with an ample amount of water. Dose for the treatment of partial onset seizures along with adjunctive therapy: A patient should consume 150mg to 600mg of Lyrica orally in a day, in two or three divided doses.
What are the contraindications of Lyrica?
- If you have hypersensitive reactions with generic Pregabalin or any other ingredients of Lyrica, then do not use this medicine.
Are there any side effects of Lyrica?
A patient may experience some side effects while relying on the treatment with Lyrica such as vague vision, constipation, wooziness, sleepiness, dry mouth, headache, enhanced appetite, tiredness, trouble in concentrating, weakness, weight gain, and change in libido,
Are there any drug interactions of Lyrica?
Some medicines alter the therapeutic effectiveness of Lyrica:
- Angiotensin-converting enzyme (ACE) inhibitors: Enalapril
- Benzodiazepines: Lorazepam
- Narcotic pain medicines: Oxycodone
- Thiazolidinedione antidiabetic agents: Rosiglitazone
Are there any safety measures to be followed while using Lyrica?
- You may feel dizzy or drowsy after the intake of Lyrica, so do not drive a vehicle or perform any risky tasks after using this medicine.
- You must avoid the use of alcoholic beverages or sleeping aids while relying on the treatment of Lyrica.
- If you have a history of depression or suicidal thoughts, then you must consult your doctor before using Lyrica medication.
- Pregnant women and lactating mothers should communicate with a doctor before using Lyrica.